Follicular dendritic cell (FDC)-FcγRIIB engagementvia immune complexes induces the activated FDC phenotype associated with secondary follicle development

Follicular dendritic cell (FDC) precursors in primary lymphoid tissues.

The origin of follicular dendritic cells (FDC) is unresolved, and as such, remains controversial. Based on the migration of Ag-transporting cells (ATC) into lymphoid follicles and the phenotypic similarity between FDC and ATC, one hypothesis is that ATC may represent emigrating FDC precursors. This contrasts with the view that FDC originate from local stromal cells in the secondary lymphoid tis...

Follicular dendritic cells (FDC) in retroviral infection: host/pathogen perspectives.

Follicular dendritic cells (FDC) are found in the follicles of virtually all secondary lymphoid tissues. In health, these cells trap and retain antigens (Ag) in the form of immune complexes and preserve them for months in their native conformation. FDC thus serve as a long-term repository of extracellular Ag important for induction and maintenance of memory responses. In retroviral infection, F...

Antibody Responses (FDC-SP) Regulates Germinal Center and Follicular Dendritic Cell Secreted Protein

FDC-SP, a novel secreted protein expressed by follicular dendritic cells.

To define better the molecular basis for follicular dendritic cell (FDC) function, we used PCR-based cDNA subtraction to identify genes specifically expressed in primary FDC isolated from human tonsils. In this work we report the discovery of a novel gene encoding a small secreted protein, which we term FDC-SP (FDC secreted protein). The FDC-SP gene lies on chromosome 4q13 adjacent to clusters ...

Progress in FDC Project

The FDC is a general-purpose program package for Feynman Diagram Calculation. We outline previous successes in calculations and focus on its recent progress about automatic deduction the Feynman rules for first principle model, especially for the supersymmetric model, proper evaluation of the rates of multi-final-particle processes and the event generators in the SM and MSSM. A few special appl...